Dynamic nanoassembly-based drug delivery system (DNDDS): Learning from nature

Xi Hu; Fangyuan Li; Fan Xia; Qiyue Wang; Peihua Lin; Min Wei; Linji Gong; Liang Ee Low; Ji Young Lee; Daishun Ling

doi:10.1016/j.addr.2021.113830

Dynamic nanoassembly-based drug delivery system (DNDDS): Learning from nature

Adv Drug Deliv Rev. 2021 Aug:175:113830. doi: 10.1016/j.addr.2021.113830. Epub 2021 Jun 15.

Authors

Xi Hu¹, Fangyuan Li², Fan Xia³, Qiyue Wang³, Peihua Lin³, Min Wei³, Linji Gong⁴, Liang Ee Low³, Ji Young Lee³, Daishun Ling⁵

Affiliations

¹ Frontiers Science Center for Transformative Molecules, School of Chemistry and Chemical Engineering, National Center of Translational Medicine, Shanghai Jiao Tong University, Shanghai 200240, China; Institute of Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.
² Institute of Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China; Hangzhou Institute of Innovative Medicine, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.
³ Institute of Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.
⁴ Frontiers Science Center for Transformative Molecules, School of Chemistry and Chemical Engineering, National Center of Translational Medicine, Shanghai Jiao Tong University, Shanghai 200240, China.
⁵ Frontiers Science Center for Transformative Molecules, School of Chemistry and Chemical Engineering, National Center of Translational Medicine, Shanghai Jiao Tong University, Shanghai 200240, China; Institute of Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China; Hangzhou Institute of Innovative Medicine, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China. Electronic address: [email protected].

PMID: 34139254
DOI: 10.1016/j.addr.2021.113830

Abstract

Dynamic nanoassembly-based drug delivery system (DNDDS) has evolved from being a mere curiosity to emerging as a promising strategy for high-performance diagnosis and/or therapy of various diseases. However, dynamic nano-bio interaction between DNDDS and biological systems remains poorly understood, which can be critical for precise spatiotemporal and functional control of DNDDS in vivo. To deepen the understanding for fine control over DNDDS, we aim to explore natural systems as the root of inspiration for researchers from various fields. This review highlights ingenious designs, nano-bio interactions, and controllable functionalities of state-of-the-art DNDDS under endogenous or exogenous stimuli, by learning from nature at the molecular, subcellular, and cellular levels. Furthermore, the assembly strategies and response mechanisms of tailor-made DNDDS based on the characteristics of various diseased microenvironments are intensively discussed. Finally, the current challenges and future perspectives of DNDDS are briefly commented.

Keywords: Biomedical imaging; Drug delivery system; Dynamic nanoassembly; Learning from nature; Therapy.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Cell Membrane / metabolism
DNA / metabolism
Exosomes / metabolism
Humans
Nanoparticle Drug Delivery System*
Nanoparticles / metabolism

Substances

Nanoparticle Drug Delivery System
DNA