Gene-edited healthy donor CAR T cells show superior anti-tumour activity compared to CAR T cells derived from patients with lymphoma in an in vivo model of high-grade lymphoma

Leukemia. 2021 Dec;35(12):3581-3584. doi: 10.1038/s41375-021-01324-z. Epub 2021 Jun 18.
No abstract available

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antigens, CD19 / genetics
  • Antigens, CD19 / immunology*
  • Antigens, CD19 / metabolism
  • Cells, Cultured
  • Disease Models, Animal
  • Gene Editing*
  • Healthy Volunteers
  • Humans
  • Immunotherapy, Adoptive / methods*
  • Lymphoma, B-Cell / immunology
  • Lymphoma, B-Cell / metabolism
  • Lymphoma, B-Cell / pathology
  • Lymphoma, B-Cell / therapy*
  • Mice
  • Receptors, Antigen, T-Cell, alpha-beta / antagonists & inhibitors
  • Receptors, Antigen, T-Cell, alpha-beta / genetics*
  • Receptors, Antigen, T-Cell, alpha-beta / metabolism

Substances

  • Antigens, CD19
  • Receptors, Antigen, T-Cell, alpha-beta