Acquired Tertiary MET Resistance (MET D1228N and a Novel LSM8-MET Fusion) to Selpercatinib and Capmatinib in a Patient With KIF5B-RET-positive NSCLC With Secondary MET Amplification as Initial Resistance to Selpercatinib

J Thorac Oncol. 2021 Jul;16(7):e51-e54. doi: 10.1016/j.jtho.2021.03.006.
No abstract available

Publication types

  • Case Reports
  • Letter

MeSH terms

  • Benzamides
  • Carcinoma, Non-Small-Cell Lung* / drug therapy
  • Carcinoma, Non-Small-Cell Lung* / genetics
  • Drug Resistance, Neoplasm*
  • Humans
  • Imidazoles
  • Lung Neoplasms* / drug therapy
  • Lung Neoplasms* / genetics
  • Oncogene Proteins, Fusion / genetics
  • Proto-Oncogene Proteins c-ret
  • Pyrazoles
  • Pyridines
  • Triazines

Substances

  • Benzamides
  • Imidazoles
  • KIF5B-RET fusion protein, human
  • Oncogene Proteins, Fusion
  • Pyrazoles
  • Pyridines
  • Triazines
  • selpercatinib
  • Proto-Oncogene Proteins c-ret
  • RET protein, human
  • capmatinib