Abstract
The pharmacokinetic studies of anticancer drugs still go on after they are out on the market. The therapeutic protocol is then more precise and depends on the dosage results of these drugs. Some examples of dosage adjustment according to their plasmatic level are reported here for high-dose methotrexate infusion and for CDDP infusion over five days. The test dose and the bayesian method (pharmacokinetic population) are used to predict the adapted individualized dosage for each patient.
MeSH terms
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Antineoplastic Agents / administration & dosage
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Antineoplastic Agents / pharmacokinetics*
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Antineoplastic Agents / therapeutic use
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Bayes Theorem
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Cisplatin / administration & dosage
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Cisplatin / pharmacokinetics
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Cisplatin / therapeutic use
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Clinical Trials as Topic*
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Evaluation Studies as Topic*
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Humans
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Methotrexate / administration & dosage
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Methotrexate / pharmacokinetics
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Methotrexate / therapeutic use
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Product Surveillance, Postmarketing*
Substances
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Antineoplastic Agents
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Cisplatin
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Methotrexate