[Targeted therapies and high blood pressure]

Rev Prat. 2021 Feb;71(2):212-215.
[Article in French]

Abstract

"Targeted therapies and hypertension The recent advent of molecular targeted agents represents an important improvement in the management of cancer patients. The administration of therapies targeting the vascular endothelial growth factor or its receptor could be associated with side effects including cardiovascular complications (hypertension, heart Failure, QT interval prolongation). Hypertension due to molecular targeted agents is considered as a class effect, which can affect nearly 90% of treated patients; its management is most often based on the introduction of anti-hypertensive treatment and more rarely on dose drug reduction."

"Thérapies ciblées et hypertension artérielle La mise à disposition des thérapies ciblées et notamment des thérapies moléculaires ciblées antiangiogéniques constitue une avancée importante dans la prise en charge des patients atteints de cancers. L’administration des thérapies ciblées ciblant le vascular endothelial growth factor ou son récepteur peut s’accompagner d’effets indésirables, dont des complications cardiovasculaires (hypertension artérielle, insuffisance cardiaque, allongement de l’intervalle QT). L’hypertension secondaire à l’administration des thérapies ciblées est un effet de classe, pouvant affecter près de 90 % des patients traités ; sa prise en charge repose le plus souvent sur l’introduction d’un traitement antihypertenseur et plus rarement sur la modulation de la posologie de la thérapie ciblée."

Keywords: Hypertension; Molecular Targeted Therapy.

MeSH terms

  • Antihypertensive Agents / adverse effects
  • Antineoplastic Agents* / therapeutic use
  • Blood Pressure
  • Heart Diseases*
  • Humans
  • Hypertension* / drug therapy
  • Vascular Endothelial Growth Factor A

Substances

  • Antihypertensive Agents
  • Antineoplastic Agents
  • Vascular Endothelial Growth Factor A