Fatal encephalopathy with brainstem involvement under dabrafenib and trametinib in a BRAF-positive metastatic melanoma

Rev Neurol (Paris). 2021 Nov;177(9):1195-1198. doi: 10.1016/j.neurol.2020.12.010. Epub 2021 Jun 22.

Authors

S Jacobs¹, S Maldonado-Slootjes¹, D Verhulst², M Gille³

Affiliations

¹ Departments of Neurology and Oncology, Cliniques de l'Europe, Brussels, Belgium.
² Cliniques de l'Europe, Brussels, Belgium.
³ Departments of Neurology and Oncology, Cliniques de l'Europe, Brussels, Belgium. Electronic address: [email protected].

PMID: 34167806
DOI: 10.1016/j.neurol.2020.12.010

No abstract available

Publication types

Letter
Comment

MeSH terms

Brain Diseases*
Brain Stem / diagnostic imaging
Humans
Imidazoles
Melanoma* / complications
Melanoma* / drug therapy
Melanoma* / genetics
Oximes
Proto-Oncogene Proteins B-raf / genetics
Pyridones
Pyrimidinones

Substances

Imidazoles
Oximes
Pyridones
Pyrimidinones
trametinib
BRAF protein, human
Proto-Oncogene Proteins B-raf
dabrafenib