Inflammatory adaptation in barrier tissues

Rachel E Niec; Alexander Y Rudensky; Elaine Fuchs

doi:10.1016/j.cell.2021.05.036

Inflammatory adaptation in barrier tissues

Cell. 2021 Jun 24;184(13):3361-3375. doi: 10.1016/j.cell.2021.05.036.

Authors

Rachel E Niec¹, Alexander Y Rudensky², Elaine Fuchs³

Affiliations

¹ Robin Chemers Neustein Laboratory of Mammalian Cell Biology and Development, Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10065, USA; Department of Gastroenterology and Hepatology, Weill Cornell Medicine, Cornell University, New York, NY 10065, USA.
² Howard Hughes Medical Institute and Ludwig Center at Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. Electronic address: [email protected].
³ Robin Chemers Neustein Laboratory of Mammalian Cell Biology and Development, Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10065, USA. Electronic address: [email protected].

Abstract

Surface epithelia provide a critical barrier to the outside world. Upon a barrier breach, resident epithelial and immune cells coordinate efforts to control infections and heal tissue damage. Inflammation can etch lasting marks within tissues, altering features such as scope and quality of future responses. By remembering inflammatory experiences, tissues are better equipped to quickly and robustly respond to barrier breaches. Alarmingly, in disease states, memory may fuel the inflammatory fire. Here, we review the cellular communication networks in barrier tissues and the integration between tissue-resident and recruited immune cells and tissue stem cells underlying tissue adaptation to environmental stress.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

MeSH terms

Adaptation, Physiological*
Animals
Humans
Inflammation / pathology*
Lymphocytes / metabolism
Models, Biological
Organ Specificity*
Stem Cells

Abstract

Publication types

MeSH terms

Grants and funding