ANXA7 Regulates Platelet Lipid Metabolism and Ca2+ Release in Arterial Thrombosis

ANXA7 Regulates Platelet Lipid Metabolism and Ca²⁺ Release in Arterial Thrombosis

Circ Res. 2021 Aug 6;129(4):494-507. doi: 10.1161/CIRCRESAHA.121.319207. Epub 2021 Jun 28.

Mailin-Christin Manke^#^{1

2}, Sascha Geue^#¹, Cristina Coman³, Bing Peng^{4

5}, Ferdinand Kollotzek^{1

2}, Patrick Münzer^{1

2}, Britta Walker¹, Stephan M Huber⁶, Dominik Rath¹, Albert Sickmann⁵, David Stegner⁷, Daniel Duerschmied⁸, Florian Lang⁹, Bernhard Nieswandt⁷, Meinrad Gawaz¹, Robert Ahrends^{3

5}, Oliver Borst^{1

2}

¹ Department of Cardiology, Angiology and Cardiovascular Medicine (M.-C.M., S.G., F.K., P.M., B.W., D.R., M.G., O.B.), University of Tübingen, Germany.
² DFG Heisenberg Group Thrombocardiology (M.-C.M., F.K., P.M., O.B.).
³ Department of Analytical Chemistry, University of Vienna, Austria (C.C., R.A.).
⁴ Division of Rheumatology, Department of Medicine Solna, Karolinska Institute, Karolinska University Hospital, Stockholm, Sweden (B.P.).
⁵ Leibniz-Institut für Analytische Wissenschaften - ISAS, Dortmund, Germany (B.P., A.S., R.A.).
⁶ Department of Radiation Oncology (S.M.H.), University of Tübingen, Germany.
⁷ Institute of Experimental Biomedicine, University Hospital and Rudolf Virchow Center for Integrative and Translational Bioimaging, University of Würzburg, Germany (D.S., B.N.).
⁸ Heart Center, Faculty of Medicine, University of Freiburg, Germany (D.D.).
⁹ Department of Physiology (F.L.), University of Tübingen, Germany.

^# Contributed equally.

[Figure: see text].

Keywords: annexin A7; calcium signaling; lipids; lipoxygenase; oxylipins; platelet activation; thrombosis.