Impact of Thyroid Autoimmunity in euthyroid women on the outcomes of In Vitro Fertilization

Ahed Hamad; Nawras Alhalabi; Nazht Nmr; Fatima Abbas; Hisham Al-Hammami; Nazir Ibrahim; Marwan Alhalabi

doi:10.1016/j.amsu.2021.102473

Impact of Thyroid Autoimmunity in euthyroid women on the outcomes of In Vitro Fertilization

Ann Med Surg (Lond). 2021 Jun 8:67:102473. doi: 10.1016/j.amsu.2021.102473. eCollection 2021 Jul.

Authors

Ahed Hamad^{1

2}, Nawras Alhalabi^{1

3}, Nazht Nmr¹, Fatima Abbas¹, Hisham Al-Hammami⁴, Nazir Ibrahim⁵, Marwan Alhalabi^{6

7}

Affiliations

¹ Faculty of Medicine, Damascus University, Damascus, Syria.
² Al-Zahrawi Maternity Hospital, Damascus, Syria.
³ Faculty of Medicine, Syrian Private University, Damascus, Syria.
⁴ Department of Obstetrics and Gynecology, Faculty of Medicine, Syrian Private University, Damascus, Syria.
⁵ Department of Internal Medicine, Faculty of Medicine, Syrian Private University, Damascus, Syria.
⁶ Division of Reproductive Medicine, Embryology and Genetics, Faculty of Medicine, Damascus University, Damascus, Syria.
⁷ Assisted Reproduction Unit, Orient Hospital, Damascus, Syria.

Abstract

Objective: Infertility is inadequately acknowledged as a problem in developing countries. Thyroid Autoimmunity (TAI) has been neatly investigated for its association with unfavorable pregnancy and reproductive consequences. We aim to evaluate Clinical Pregnancy Rate (CPR) as a primary outcome following In Vitro Fertilization/Intra Cytoplasmic Sperm Injection (IVF/ICSI) in women with Thyroid Autoimmunity (TAI).

Methods: A Retrospective cohort study included 584 women who underwent IVF/ICSI treatment between November 2012 and April 2017 in Orient Hospital, Damascus, Syria. Patients were tested for TAI before IVF/ICSI procedure.

Results: CPR did not significantly differ between TAI positive and TAI negative groups (p > 0.05). Subgroup analysis for only primary infertility patients showed a statistically significant difference in CPR between TAI positive and TAI negative groups.

Conclusion: Although several arguments were in favor of the relation between IVF/ICSI outcomes and Thyroid autoimmune disease, the presence of TAI positivity did not adversely affect the clinical pregnancy rate.

Keywords: Clinical pregnancy rate (CPR); In vitro fertilization (IVF); Intra cytoplasmic sperm injection (ICSI); Syria; Thyroid autoimmunity (TAI).