Thalamo-cortical spiking model of incremental learning combining perception, context and NREM-sleep

PLoS Comput Biol. 2021 Jun 28;17(6):e1009045. doi: 10.1371/journal.pcbi.1009045. eCollection 2021 Jun.

Abstract

The brain exhibits capabilities of fast incremental learning from few noisy examples, as well as the ability to associate similar memories in autonomously-created categories and to combine contextual hints with sensory perceptions. Together with sleep, these mechanisms are thought to be key components of many high-level cognitive functions. Yet, little is known about the underlying processes and the specific roles of different brain states. In this work, we exploited the combination of context and perception in a thalamo-cortical model based on a soft winner-take-all circuit of excitatory and inhibitory spiking neurons. After calibrating this model to express awake and deep-sleep states with features comparable with biological measures, we demonstrate the model capability of fast incremental learning from few examples, its resilience when proposed with noisy perceptions and contextual signals, and an improvement in visual classification after sleep due to induced synaptic homeostasis and association of similar memories.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Action Potentials*
  • Algorithms
  • Cerebral Cortex / cytology
  • Cerebral Cortex / physiology*
  • Homeostasis
  • Humans
  • Learning
  • Models, Neurological*
  • Neurons / physiology
  • Sleep, REM / physiology*
  • Synapses / physiology
  • Thalamus / cytology
  • Thalamus / physiology*

Grants and funding

This work has been supported by the European Union Horizon 2020 Research and Innovation program under the FET Flagship Human Brain Project (grant agreement SGA3 n. 945539 and grant agreement SGA2 n. 785907; recipient Pier Stanislao Paolucci) and by the INFN APE Parallel/Distributed Computing laboratory. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.