Homocysteine elevation in givosiran treatment: Suggested ALAS1 siRNA effect on cystathionine beta-synthase

J Intern Med. 2021 Oct;290(4):928-930. doi: 10.1111/joim.13341. Epub 2021 Jun 29.

Authors

Daphne Vassiliou^{1

2

3}, Eliane Sardh^{1

2

3}

Affiliations

¹ Department of Endocrinology, Karolinska University Hospital, Solna, Sweden.
² Department of Molecular Medicine and Surgery (MMK), Karolinska Institutet, Solna, Sweden.
³ Porphyria Centre Sweden, Centre for Inherited Metabolic Diseases (CMMS), Karolinska University Hospital, Solna, Sweden.

PMID: 34184789
DOI: 10.1111/joim.13341

No abstract available

Keywords: hyperhomocysteinaemia; porphyria.

Publication types

Letter

MeSH terms

Acetylgalactosamine / analogs & derivatives*
Acetylgalactosamine / therapeutic use
Cystathionine beta-Synthase* / genetics
Homocysteine* / blood
Humans
Pyrrolidines / therapeutic use*
RNA, Small Interfering* / genetics

Substances

Pyrrolidines
RNA, Small Interfering
Homocysteine
Cystathionine beta-Synthase
Acetylgalactosamine
givosiran