Mechanism of mitotic recombination: insights from C. elegans

Curr Opin Genet Dev. 2021 Dec:71:10-18. doi: 10.1016/j.gde.2021.06.005. Epub 2021 Jun 26.

Abstract

Homologous recombination (HR) plays a critical role in largely error-free repair of mitotic and meiotic DNA double-strand breaks (DSBs). DSBs are one of the most deleterious DNA lesions, which are repaired by non-homologous end joining (NHEJ), homologous recombination (HR) or, if compromised, micro-homology mediated end joining (MMEJ). If left unrepaired, DSBs can lead to cell death or if repaired incorrectly can result in chromosome rearrangements that drive cancer development. Here, we describe recent advances in the field of mitotic HR made using Caenorhabditis elegans roundworm, as a model system.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Caenorhabditis elegans* / genetics
  • DNA Breaks, Double-Stranded
  • DNA End-Joining Repair*
  • DNA Repair
  • DNA Replication
  • Homologous Recombination / genetics