Case Report: Emergent Resistance in a Treatment-Naive Person With Human Immunodeficiency Virus Under Bictegravir-Based Therapy

Nicholas Chamberlain; Leandro Mena; James Benjamin Brock

doi:10.1093/ofid/ofab297

Case Report: Emergent Resistance in a Treatment-Naive Person With Human Immunodeficiency Virus Under Bictegravir-Based Therapy

Open Forum Infect Dis. 2021 Jun 4;8(6):ofab297. doi: 10.1093/ofid/ofab297. eCollection 2021 Jun.

Authors

Nicholas Chamberlain¹, Leandro Mena², James Benjamin Brock¹

Affiliations

¹ Division of Infectious Diseases, Department of Medicine, University of Mississippi Medical Center, Jackson, Mississippi, USA.
² Department of Population Health Science, University of Mississippi Medical Center, Jackson, Mississippi, USA.

Abstract

Few instances of treatment-emergent resistance to bictegravir have been reported in the literature. We describe a case of treatment-emergent resistance to bictegravir in a person recently diagnosed with human immunodeficiency virus who developed M184V and R263K mutations while on therapy.

Keywords: HIV; R263K; bictegravir; resistance.