Punctate Anetoderma After Colony-Stimulating Factor 1 Receptor and Programmed Cell Death 1 Blockade With Irradiation: Clinicopathologic Characterization of a Novel Eruption

Julia Dai; Yuanyuan Zha; Corey C Foster; Jason J Luke; Steven J Chmura; Mark D Hoffman

doi:10.1001/jamadermatol.2021.2049

Punctate Anetoderma After Colony-Stimulating Factor 1 Receptor and Programmed Cell Death 1 Blockade With Irradiation: Clinicopathologic Characterization of a Novel Eruption

JAMA Dermatol. 2021 Aug 1;157(8):998-1000. doi: 10.1001/jamadermatol.2021.2049.

Authors

Julia Dai¹, Yuanyuan Zha², Corey C Foster³, Jason J Luke⁴, Steven J Chmura⁵, Mark D Hoffman¹

Affiliations

¹ Section of Dermatology, Department of Medicine, University of Chicago Medical Center, Chicago, Illinois.
² Department of Pathology, University of Chicago Medical Center, Chicago, Illinois.
³ Department of Radiation Oncology, Vanderbilt University Medical Center, Nashville, Tennessee.
⁴ Section of Hematology/Oncology, University of Pittsburgh Medical Center, Hillman Cancer Center, Pittsburgh, Pennsylvania.
⁵ Department of Radiation and Cellular Oncology, University of Chicago Medical Center, Chicago, Illinois.

Abstract

This case series observes 5 patients treated with nivolumab and cabiralizumab with stereotactic radiotherapy who developed punctate, atrophic depressions with histologic findings of elastolysis.

Publication types

Case Reports
Letter

MeSH terms

Anetoderma* / chemically induced
Apoptosis
Exanthema* / chemically induced
Humans
Neoplasm Proteins / antagonists & inhibitors*
Receptors, Granulocyte-Macrophage Colony-Stimulating Factor / antagonists & inhibitors*
Transcription Factors / antagonists & inhibitors*

Substances

CSF1R protein, human
Neoplasm Proteins
PCD1 protein, human
Receptors, Granulocyte-Macrophage Colony-Stimulating Factor
Transcription Factors