What Is the Catalytic Mechanism of Enzymatic Histone N-Methyl Arginine Demethylation and Can It Be Influenced by an External Electric Field?

Rajeev Ramanan; Sodiq O Waheed; Christopher J Schofield; Christo Z Christov

doi:10.1002/chem.202102158

What Is the Catalytic Mechanism of Enzymatic Histone N-Methyl Arginine Demethylation and Can It Be Influenced by an External Electric Field?

Chemistry. 2021 Aug 16;27(46):11750. doi: 10.1002/chem.202102158. Epub 2021 Jun 30.

Authors

Rajeev Ramanan^{1

2}, Sodiq O Waheed¹, Christopher J Schofield³, Christo Z Christov¹

Affiliations

¹ Department of Chemistry, Michigan Technological University, Houghton, Michigan, 49931, USA.
² Present address: Department of Chemistry, National Institute of Technology, Rourkela, Odisha, 769001, India.
³ The Department of Chemistry and the Ineos Oxford Institute for, Antimicrobial Research, The Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford, OX1 5JJ, UK.

PMID: 34191375
DOI: 10.1002/chem.202102158

Abstract

Invited for the cover of this issue are Christo Z. Christov and co-workers at Michigan Technological University and University of Oxford. The image depicts the effects of applying an external electric field on the demethylation of dimethylated arginine substrate by a non-heme Fe center Histone N-methyl arginine demethylase. Read the full text of the article at 10.1002/chem.202101174.