Keywords: BRAF; BRAF inhibitor; BRAFi, BRAF inhibitors; CTLA4; DIHS; DIHS, drug-induced hypersensitivity syndrome; DLR, DIHS-like reaction; DRESS; ICI; ICI, immune checkpoint inhibitor; PD-1; PD-L1; PD1; TT, targeted therapy; dabrafenib; encorafenib; immune checkpoint therapy; immune related adverse effect; irAE; ircAE; oncoderm; rash; vemurafenib.