Protein Causes of Urticaria and Dermatitis

Alyssa Gwen Ashbaugh; Mary Kathryn Abel; Jenny E Murase

doi:10.1016/j.iac.2021.04.008

Protein Causes of Urticaria and Dermatitis

Immunol Allergy Clin North Am. 2021 Aug;41(3):481-491. doi: 10.1016/j.iac.2021.04.008. Epub 2021 Jun 5.

Authors

Alyssa Gwen Ashbaugh¹, Mary Kathryn Abel², Jenny E Murase³

Affiliations

¹ Department of Dermatology, University of California, San Francisco, Third and Fourth Floors, 1701 Divisadero St, San Francisco, CA 94115, USA; School of Medicine, University of California, Irvine, 1001 Health Sciences Rd, Irvine, CA 92617, USA.
² Department of Dermatology, University of California, San Francisco, Third and Fourth Floors, 1701 Divisadero St, San Francisco, CA 94115, USA; School of Medicine, University of California, San Francisco, 533 Parnassus Ave, San Francisco, CA 94143, USA.
³ Department of Dermatology, University of California, San Francisco, Third and Fourth Floors, 1701 Divisadero St, San Francisco, CA 94115, USA; Department of Dermatology, Palo Alto Foundation Medical Group, 701 East El Camino Real (31-104), Mountain View, CA 94040, USA. Electronic address: [email protected].

PMID: 34225902
DOI: 10.1016/j.iac.2021.04.008

Abstract

Protein contact dermatitis is a cutaneous hypersensitivity reaction after chronic, recurrent exposure or chronic irritation to animal or plant protein. Although the pathophysiological mechanisms underlying protein contact dermatitis are not well characterized, protein contact dermatitis is thought to be caused by combined type I/IV-mediated, type-1 mediated, or a Langerhans cell immunoglobulin E-mediated delayed hypersensitivity reaction. This chapter reviews the epidemiology, pathogenesis, clinical features, common protein allergens, diagnostic process, treatment options, and prognosis of protein contact dermatitis.

Keywords: Allergy; Cutaneous hypersensitivity reaction; Protein contact dermatitis.

Publication types

Review

MeSH terms

Allergens
Animals
Dermatitis, Allergic Contact*
Dermatitis, Atopic*
Dermatitis, Contact*
Humans
Immunoglobulin E
Urticaria* / diagnosis
Urticaria* / epidemiology
Urticaria* / etiology

Substances

Allergens
Immunoglobulin E