Hyperhomocysteinemia in patients with acute porphyrias: a possible effect of ALAS1 modulation by siRNAm therapy and its control by vitamin supplementation

Eur J Intern Med. 2021 Oct:92:121-123. doi: 10.1016/j.ejim.2021.06.023. Epub 2021 Jul 3.

Authors

Andrea Ricci¹, Matteo Marcacci¹, Chiara Cuoghi¹, Antonello Pietrangelo¹, Paolo Ventura²

Affiliations

¹ Internal Medicine Unit, Department of Medical and Surgical Science for Children and Adults,University of Modena e Reggio Emilia.
² Internal Medicine Unit, Department of Medical and Surgical Science for Children and Adults,University of Modena e Reggio Emilia. Electronic address: [email protected].

PMID: 34226116
DOI: 10.1016/j.ejim.2021.06.023

No abstract available

Keywords: ALAS1 siRNAm; Acute porphyrias; Givosiran; Heme; Homocysteine; Vitamin B6.

Publication types

Letter

MeSH terms

Dietary Supplements
Folic Acid
Homocysteine
Humans
Hyperhomocysteinemia* / drug therapy
Porphyria, Acute Intermittent*
Vitamin B 12
Vitamins / therapeutic use

Substances

Vitamins
Homocysteine
Folic Acid
Vitamin B 12