Hidden mysteries behind genome, epigenome, and exposome of lupus erythematosus

Hui Jin; Ming Zhao; Qianjin Lu

doi:10.1016/j.molmed.2021.06.006

Hidden mysteries behind genome, epigenome, and exposome of lupus erythematosus

Trends Mol Med. 2021 Sep;27(9):839-843. doi: 10.1016/j.molmed.2021.06.006. Epub 2021 Jul 3.

Authors

Hui Jin¹, Ming Zhao², Qianjin Lu³

Affiliations

¹ Department of Dermatology, Hunan Key Laboratory of Medical Epigenomics, The Second Xiangya Hospital, Central South University, Changsha, China; Research Unit of Key Technologies of Immune-related Skin Diseases Diagnosis and Treatment, Chinese Academy of Medical Sciences (2019RU027), Changsha, China.
² Department of Dermatology, Hunan Key Laboratory of Medical Epigenomics, The Second Xiangya Hospital, Central South University, Changsha, China; Research Unit of Key Technologies of Immune-related Skin Diseases Diagnosis and Treatment, Chinese Academy of Medical Sciences (2019RU027), Changsha, China. Electronic address: [email protected].
³ Department of Dermatology, Hunan Key Laboratory of Medical Epigenomics, The Second Xiangya Hospital, Central South University, Changsha, China; Research Unit of Key Technologies of Immune-related Skin Diseases Diagnosis and Treatment, Chinese Academy of Medical Sciences (2019RU027), Changsha, China; Institute of Dermatology, Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, China; Key Laboratory of Basic and Translational Research on Immune-Mediated Skin Diseases, Chinese Academy of Medical Sciences, Nanjing, China; Jiangsu Key Laboratory of Molecular Biology for Skin Diseases and STIs, Nanjing, Jiangsu 210042, China. Electronic address: [email protected].

PMID: 34226151
DOI: 10.1016/j.molmed.2021.06.006

Abstract

As an extremely heterogeneous disease, lupus erythematosus (LE) occurs when a genetically susceptible individual encounters specific environmental triggers. Epigenetics bridges genetics and environment and helps explain their interactions. Comprehensively understanding the hidden mysteries behind the genome, epigenome, and exposome of lupus could contribute to precision prevention and treatment of lupus.

Keywords: cutaneous lupus erythematosus; environment; epigenetic; heredity; inheritance; systemic lupus erythematosus.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Epigenesis, Genetic
Epigenome
Exposome*
Humans
Lupus Erythematosus, Discoid*
Lupus Erythematosus, Systemic* / genetics