Immune cells infiltrating tumors are capable of significantly impacting carcinogenesis through cancer promotion and anticancer responses. There are many aspects of hepatocellular carcinoma (HCC) related T lymphocytes that are undergoing extensive studies, whereas the effect exerted by B lymphocytes remains a less researched area. In this study, the latest research on the effect of B lymphocytes as they infiltrate tumors in relation to HCC is presented. Their prognosis-related importance is analyzed, along with their function in the tumor microenvironment (TME), as well as the way that B cell biology can be employed to help create a B cell therapy strategy for HCC.
Keywords: B lymphocyte; hepatocellular carcinoma; immunity; immunotherapy; tumor-infiltrating B lymphocyte.
Copyright © 2021 Qin, Wang, Fang, Zheng, Liu, Wu, Wang, Li, Hui, Ma, Tang and Pan.