High-Content Analysis Monitoring Intracellular Trafficking and Replication of Mycobacterium tuberculosis Inside Host Cells

Methods Mol Biol. 2021:2314:649-702. doi: 10.1007/978-1-0716-1460-0_29.

Abstract

Mycobacterium tuberculosis is able to colonize, persist, and massively replicate in host cells, such as phagocytes and epithelial cells. The intracellular stage of the bacteria is critical to the development of tuberculosis pathogenesis. The detailed mechanisms of intracellular trafficking of the bacillus are not fully understood and require further investigations. Therefore, increasing the knowledge of this process will help to develop therapeutic tools that will lower the burden of tuberculosis. M. tuberculosis is genetically tractable and tolerates the expression of heterologous fluorescent proteins. Thus, the intracellular distribution of the bacteria expressing fluorescent tracers can be easily defined using confocal microscopy. Advances in imaging techniques and images-based analysis allow the rapid quantification of biological objects in complex environments. In this chapter, we detailed high-content / high-throughput imaging methods to track the bacillus within host cell settings.

Keywords: Automated confocal microscopy; Drug discovery; High-content/high-throughput screening; Image-based analysis; Mycobacterium tuberculosis; Phenotypic assays; siRNA library.

MeSH terms

  • Animals
  • Dendritic Cells / metabolism
  • Dendritic Cells / microbiology*
  • Diagnostic Tests, Routine
  • Epithelial Cells / metabolism
  • Epithelial Cells / microbiology*
  • High-Throughput Screening Assays / methods*
  • Humans
  • Macrophages / metabolism
  • Macrophages / microbiology*
  • Mice
  • Mycobacterium tuberculosis / growth & development*
  • Mycobacterium tuberculosis / pathogenicity
  • Oxidative Stress
  • Phagocytes / metabolism
  • Phagocytes / microbiology*
  • Reactive Oxygen Species
  • Tuberculosis / metabolism
  • Tuberculosis / microbiology*

Substances

  • Reactive Oxygen Species