Antibody-dependent neutralizing capacity of the SARS-CoV-2 vaccine BNT162b2 with and without previous COVID-19 priming

Cecilie Bo Hansen; Ida Jarlhelt; Rasmus Bo Hasselbalch; Sebastian Rask Hamm; Kamille Fogh; Mia Marie Pries-Heje; Dina Leth Møller; Line Dam Heftdal; Laura Pérez-Alós; Erik Sørensen; Margit Anita Hørup Larsen; Mikkel-Ole Skjoedt; Sisse Rye Ostrowski; Ruth Frikke-Schmidt; Rafael Bayarri-Olmos; Linda Maria Hilsted; Henning Bundgaard; Susanne Dam Nielsen; Kasper Karmark Iversen; Peter Garred

doi:10.1111/joim.13366

Antibody-dependent neutralizing capacity of the SARS-CoV-2 vaccine BNT162b2 with and without previous COVID-19 priming

J Intern Med. 2021 Dec;290(6):1272-1274. doi: 10.1111/joim.13366. Epub 2021 Aug 2.

Authors

Cecilie Bo Hansen¹, Ida Jarlhelt¹, Rasmus Bo Hasselbalch^{2

3}, Sebastian Rask Hamm⁴, Kamille Fogh^{2

3}, Mia Marie Pries-Heje⁵, Dina Leth Møller⁴, Line Dam Heftdal^{4

6}, Laura Pérez-Alós¹, Erik Sørensen⁷, Margit Anita Hørup Larsen⁷, Mikkel-Ole Skjoedt¹, Sisse Rye Ostrowski^{7

8}, Ruth Frikke-Schmidt^{8

9}, Rafael Bayarri-Olmos¹, Linda Maria Hilsted⁹, Henning Bundgaard^{6

8}, Susanne Dam Nielsen^{4

8}, Kasper Karmark Iversen^{2

3

8}, Peter Garred^{1

8}

Affiliations

¹ Laboratory of Molecular Medicine, Department of Clinical Immunology, Section 7631, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
² Department of Cardiology, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.
³ Department of Emergency medicine, Herlev and Gentofte Hospital, University of Copenhagen, Denmark.
⁴ Department of Infectious Diseases, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
⁵ Department of Cardiology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
⁶ Department of Haematology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
⁷ Department of Clinical Immunology, Section 2034, Blood Bank, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
⁸ Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
⁹ Department of Clinical Biochemistry, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.

No abstract available

Keywords: BNT162b2; COVID-19; IgA; IgG; IgM; RBD; SARS-CoV-2; antibody neutralization; antibody response; immunoassays; nucleocapsid protein; serology; vaccine.

Publication types

Letter

MeSH terms

Antibodies, Neutralizing*
Antibodies, Viral / immunology*
Antibody Formation
BNT162 Vaccine
COVID-19 / epidemiology
COVID-19 / immunology*
COVID-19 / prevention & control*
COVID-19 Vaccines / administration & dosage
COVID-19 Vaccines / genetics
COVID-19 Vaccines / immunology*
Denmark
Health Personnel
Humans
Immunogenicity, Vaccine
Immunoglobulin G / immunology
RNA, Messenger / administration & dosage
RNA, Messenger / genetics
RNA, Messenger / immunology*
SARS-CoV-2 / genetics
SARS-CoV-2 / immunology*

Substances

Antibodies, Neutralizing
Antibodies, Viral
COVID-19 Vaccines
Immunoglobulin G
RNA, Messenger
BNT162 Vaccine