Hsp70 chaperones TDP-43 in dynamic, liquid-like phase and prevents it from amyloid aggregation

Jinge Gu; Chen Wang; Rirong Hu; Yichen Li; Shengnan Zhang; Yunpeng Sun; Qiangqiang Wang; Dan Li; Yanshan Fang; Cong Liu

doi:10.1038/s41422-021-00526-5

Hsp70 chaperones TDP-43 in dynamic, liquid-like phase and prevents it from amyloid aggregation

Cell Res. 2021 Sep;31(9):1024-1027. doi: 10.1038/s41422-021-00526-5. Epub 2021 Jul 8.

Authors

Jinge Gu^#^{1

2}, Chen Wang^#^{1

2}, Rirong Hu^#^{1

2}, Yichen Li³, Shengnan Zhang^{1

2}, Yunpeng Sun^{1

2}, Qiangqiang Wang¹, Dan Li³, Yanshan Fang^{4

5}, Cong Liu^{6

7}

Affiliations

¹ Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, China.
² University of Chinese Academy of Sciences, Beijing, China.
³ Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders, Ministry of Education, Shanghai Jiao Tong University, Shanghai, China.
⁴ Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, China. [email protected].
⁵ University of Chinese Academy of Sciences, Beijing, China. [email protected].
⁶ Interdisciplinary Research Center on Biology and Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, China. [email protected].
⁷ University of Chinese Academy of Sciences, Beijing, China. [email protected].

^# Contributed equally.

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Amyloid*
DNA-Binding Proteins
HSP70 Heat-Shock Proteins*
Molecular Chaperones

Substances

Amyloid
DNA-Binding Proteins
HSP70 Heat-Shock Proteins
Molecular Chaperones

Publication types

MeSH terms

Substances

Grants and funding