Biologically active metabolites in drug discovery

Shaoyi Sun; Steven S Wesolowski

doi:10.1016/j.bmcl.2021.128255

Biologically active metabolites in drug discovery

Bioorg Med Chem Lett. 2021 Sep 15:48:128255. doi: 10.1016/j.bmcl.2021.128255. Epub 2021 Jul 7.

Authors

Shaoyi Sun¹, Steven S Wesolowski²

Affiliations

¹ Xenon Pharmaceuticals Inc, 200-3650 Gilmore Way, Burnaby, BC V5G 4W8, Canada. Electronic address: [email protected].
² Xenon Pharmaceuticals Inc, 200-3650 Gilmore Way, Burnaby, BC V5G 4W8, Canada.

PMID: 34245850
DOI: 10.1016/j.bmcl.2021.128255

Abstract

Biologically active metabolites are a valuable resource for development of drug candidates and lead structures for drug design. This digest highlights a selection of biologically active metabolites that have been used as new chemical entities for development or as lead structures for drug design.

Keywords: Drug; Metabolite.

Publication types

Review

MeSH terms

Drug Discovery*
Molecular Structure
Pharmaceutical Preparations / chemical synthesis
Pharmaceutical Preparations / chemistry
Pharmaceutical Preparations / metabolism*
Small Molecule Libraries / chemical synthesis
Small Molecule Libraries / chemistry
Small Molecule Libraries / metabolism*

Substances

Pharmaceutical Preparations
Small Molecule Libraries