How can polyreactive antibodies conquer rapidly evolving viruses?

Alejandra Reyes-Ruiz; Jordan D Dimitrov

doi:10.1016/j.it.2021.06.008

How can polyreactive antibodies conquer rapidly evolving viruses?

Trends Immunol. 2021 Aug;42(8):654-657. doi: 10.1016/j.it.2021.06.008. Epub 2021 Jul 7.

Authors

Alejandra Reyes-Ruiz¹, Jordan D Dimitrov²

Affiliations

¹ Centre de Recherche des Cordeliers, INSERM, Sorbonne Université, Université de Paris, 75006 Paris, France.
² Centre de Recherche des Cordeliers, INSERM, Sorbonne Université, Université de Paris, 75006 Paris, France. Electronic address: [email protected].

PMID: 34246558
DOI: 10.1016/j.it.2021.06.008

Abstract

Broadly neutralizing antibodies against rapidly evolving viruses (e.g., HIV-1 and influenza virus), often manifest antigen-binding promiscuity. Based on a recent study, we hypothesize on the significance of antibody polyreactivity in neutralization of rapidly evolving viruses. We propose that polyreactivity contributes to toleration of viral variants and shortens the time for generating neutralizing antibodies.

Keywords: HIV-1; antibodies; broadly neutralizing antibodies; influenza virus; polyreactivity; viruses.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adaptive Immunity
Antibodies, Neutralizing
Antibodies, Viral
HIV Antibodies
HIV-1*
Humans
Orthomyxoviridae*

Substances

Antibodies, Neutralizing
Antibodies, Viral
HIV Antibodies