Proteomics: A prospective new tool in forensic investigations

Over the last few decades, DNA evidence has become a very powerful tool in forensics, but it also has its limitations. DNA, being a very fragile molecule, can be easily damaged and contaminated. It can be very challenging to find enough DNA in an investigation to really make a breakthrough in certain types of evidence samples. For instance, about half of all rape kits do not yield sufficient genetic information to determine the perpetrator's DNA profile. This is where proteomics, the modern concept of protein analysis, steps in. By observing the amino acid sequence of protein fragments, researchers can work backward to conclude the DNA sequence used to make proteins. Proteomics methods can be used to classify and explain the circumstances that produced the biological samples. This article provides a conceptual overview on the different proteomics applications in forensics, including human identification using hair samples and fingermarks, species determination utilizing teeth and bones, and the determination of postmortem intervals.