Abstract
Evidences highlight the role of various CD4+ helper T cells (CD4+ Th) subpopulations in orchestrating the immune responses against cancers. Epigenetics takes an important part in the regulation of CD4+ Th polarization and plasticity. In this review, we described the epigenetic factors that govern CD4+ T cells differentiation and recruitment in the tumor microenvironment and their subsequent involvement in the antitumor immunity. Finally, we discussed how to manipulate tumor reactive CD4+ Th responses by epigenetic drugs to improve anticancer immunotherapy.
Keywords:
CD4+ helper T cells; epigenetics; immunotherapy; plasticity; tumor microenvironment.
Copyright © 2021 Renaude, Kroemer, Borg, Peixoto, Hervouet, Loyon and Adotévi.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Antineoplastic Agents / adverse effects
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Antineoplastic Agents / therapeutic use*
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Cell Differentiation / drug effects
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Cellular Reprogramming / drug effects*
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Epigenesis, Genetic / drug effects*
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Humans
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Immunotherapy, Adoptive* / adverse effects
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Lymphocytes, Tumor-Infiltrating / drug effects*
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Lymphocytes, Tumor-Infiltrating / immunology
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Lymphocytes, Tumor-Infiltrating / metabolism
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Neoplasms / genetics
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Neoplasms / immunology
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Neoplasms / metabolism
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Neoplasms / therapy*
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T-Lymphocytes, Helper-Inducer / drug effects*
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T-Lymphocytes, Helper-Inducer / immunology
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T-Lymphocytes, Helper-Inducer / metabolism
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T-Lymphocytes, Helper-Inducer / transplantation*
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Treatment Outcome
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Tumor Microenvironment