Redefining actin dynamics of the pointed-end complex in striated muscle

Jessika Iwanski; Carol C Gregorio; Mert Colpan

doi:10.1016/j.tcb.2021.06.006

Redefining actin dynamics of the pointed-end complex in striated muscle

Trends Cell Biol. 2021 Sep;31(9):708-711. doi: 10.1016/j.tcb.2021.06.006. Epub 2021 Jul 12.

Authors

Jessika Iwanski¹, Carol C Gregorio², Mert Colpan¹

Affiliations

¹ Department of Cellular and Molecular Medicine, and Sarver Molecular Cardiovascular Research Program, The University of Arizona, Tucson, AZ 85724, USA.
² Department of Cellular and Molecular Medicine, and Sarver Molecular Cardiovascular Research Program, The University of Arizona, Tucson, AZ 85724, USA. Electronic address: [email protected].

Abstract

Striated muscle is intricately designed to provide efficient and powerful muscle contractions. Recently, a long sought-after missing component of the thin filament pointed-end machinery was discovered: cyclase-associated protein 2 (CAP2). CAP2 was identified as a crucial contributor to actin polymerization, striated muscle development, and severe muscle disease when mutated.

Keywords: actin; muscle; myopathy; sarcomere; thin filament.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Actin Cytoskeleton*
Actins* / genetics
Humans
Muscle Contraction
Muscle Development
Muscle, Skeletal

Substances

Actins

Abstract

Publication types

MeSH terms

Substances

Grants and funding