Intraoperative ketorolac may interact with patient-specific tumour genomics to modify recurrence risk in lung adenocarcinoma: an exploratory analysis

Br J Anaesth. 2021 Sep;127(3):e82-e85. doi: 10.1016/j.bja.2021.05.032. Epub 2021 Jul 14.
No abstract available

Keywords: RNA sequencing; ketorolac; lung adenocarcinoma; next-generation sequencing; recurrence.

Publication types

  • Letter
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Adenocarcinoma of Lung / genetics
  • Adenocarcinoma of Lung / mortality
  • Adenocarcinoma of Lung / pathology
  • Adenocarcinoma of Lung / surgery*
  • Anti-Inflammatory Agents, Non-Steroidal / administration & dosage
  • Anti-Inflammatory Agents, Non-Steroidal / adverse effects*
  • Biomarkers, Tumor / genetics*
  • Gene Regulatory Networks
  • Genomics
  • Humans
  • Intraoperative Care
  • Ketorolac / administration & dosage
  • Ketorolac / adverse effects*
  • Lung Neoplasms / genetics
  • Lung Neoplasms / mortality
  • Lung Neoplasms / pathology
  • Lung Neoplasms / surgery*
  • NF-E2-Related Factor 2 / genetics
  • Neoplasm Recurrence, Local*
  • Pneumonectomy* / adverse effects
  • Pneumonectomy* / mortality
  • Proto-Oncogene Proteins c-mdm2 / genetics
  • Risk Assessment
  • Risk Factors
  • Time Factors
  • Treatment Outcome

Substances

  • Anti-Inflammatory Agents, Non-Steroidal
  • Biomarkers, Tumor
  • NF-E2-Related Factor 2
  • NFE2L2 protein, human
  • MDM2 protein, human
  • Proto-Oncogene Proteins c-mdm2
  • Ketorolac