Abstract
Flunarizine was tested for prophylactic efficacy and for side effects in 10- to 13-year-old patients with severe migraine (greater than 2 attacks per month). The 13 preadolescents received a single 5-mg dose at night for 2 months. The attack frequency decreased significantly, and the effect was maintained over time. The endocrine status, investigated before and after treatment, showed no significant interference with pituitary, beta-pancreatic, or gonadal function.
MeSH terms
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Adolescent
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Adrenal Cortex Hormones / blood
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Blood Glucose / metabolism
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Child
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Female
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Flunarizine / administration & dosage*
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Flunarizine / adverse effects
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Flunarizine / therapeutic use
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Glycated Hemoglobin / metabolism
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Gonadal Steroid Hormones / blood
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Humans
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Male
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Migraine Disorders / blood
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Migraine Disorders / prevention & control*
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Pituitary Hormones / blood
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Thyroid Hormones / blood
Substances
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Adrenal Cortex Hormones
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Blood Glucose
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Glycated Hemoglobin A
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Gonadal Steroid Hormones
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Pituitary Hormones
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Thyroid Hormones
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Flunarizine