A turn-on probe for detecting antituberculotic drug-induced liver injury in mice via NIR-II fluorescence/optoacoustic imaging

Longqi Chen; Junjie Chen; Yichang Fang; Fang Zeng; Shuizhu Wu

doi:10.1039/d1cc02845f

A turn-on probe for detecting antituberculotic drug-induced liver injury in mice via NIR-II fluorescence/optoacoustic imaging

Chem Commun (Camb). 2021 Aug 5;57(63):7842-7845. doi: 10.1039/d1cc02845f.

Authors

Longqi Chen¹, Junjie Chen¹, Yichang Fang¹, Fang Zeng¹, Shuizhu Wu¹

Affiliation

¹ State Key Laboratory of Luminescent Materials and Devices, Guangdong Provincial Key Laboratory of Luminescence from Molecular Aggregates, College of Materials Science and Engineering, South China University of Technology, Guangzhou 510640, China. [email protected] [email protected].

PMID: 34278391
DOI: 10.1039/d1cc02845f

Abstract

A turn-on optoacoustic and NIR-II fluorescent probe for imaging antituberculotic drug-induced liver injury has been developed. Probe TC-H2O2 responds to hepatic H2O2, thus releasing chromophore TC-NN, which displays prominent NIR-II fluorescence and optoacoustic signals for diagnosing liver injury.

MeSH terms

Animals
Antitubercular Agents / adverse effects
Antitubercular Agents / analysis*
Chemical and Drug Induced Liver Injury / diagnostic imaging*
Fluorescent Dyes / chemistry*
Infrared Rays
Mice
Molecular Structure
Optical Imaging*
Photoacoustic Techniques*
RAW 264.7 Cells

Substances

Antitubercular Agents
Fluorescent Dyes