Effects of a stable analogue of PGE2 (11-deoxy-13,14-didehydro-16 (S)-methylester methyl PGE2: FCE 20700) on the secretory processes of conjunctival goblet cells of rabbit

P Aragona; V Candela; A P Caputi; A Micali; D Puzzolo; M Quintieri

doi:10.1016/s0014-4835(87)80113-6

Effects of a stable analogue of PGE2 (11-deoxy-13,14-didehydro-16 (S)-methylester methyl PGE2: FCE 20700) on the secretory processes of conjunctival goblet cells of rabbit

Exp Eye Res. 1987 Nov;45(5):647-54. doi: 10.1016/s0014-4835(87)80113-6.

Authors

P Aragona¹, V Candela, A P Caputi, A Micali, D Puzzolo, M Quintieri

Affiliation

¹ Department of Ophthalmology, Messina University, Italy.

PMID: 3428390
DOI: 10.1016/s0014-4835(87)80113-6

Abstract

The effects of the instillation of a PGE2-analogue (11-deoxy-13,14-didehydro-16 (S)-methyl PGE2 methylester: FCE 20700) in the conjunctival sac of the rabbit were studied by means of two methods. The former is a clinical study (Dohlman test), the latter is a morphological investigation (semithin sections) on specimens of the conjunctival mucosa. From both methods it was possible to demonstrate that the FCE 20700 instillation enhanced the mucous lacrimal secretion in rabbits.

MeSH terms

Animals
Cell Count
Conjunctiva / cytology
Conjunctiva / drug effects*
Conjunctiva / metabolism
Cytoplasmic Granules / drug effects
Dinoprostone* / analogs & derivatives*
Epithelial Cells
Epithelium / drug effects
Exocrine Glands / cytology
Male
Mucus / metabolism
Prostaglandins E, Synthetic / pharmacology*
Rabbits
Stimulation, Chemical
Tears / metabolism
Time Factors

Substances

Prostaglandins E, Synthetic
FCE 20700
Dinoprostone