During the July 2020 first wave of severe acute respiratory syndrome coronavirus 2 in Zambia, PCR-measured prevalence was 13.4% among outpatients at health facilities, an absolute difference of 5.7% compared with prevalence among community members. This finding suggests that facility testing might be an effective strategy during high community transmission.
Keywords: SARS-CoV-2; Zambia; coronavirus disease; disease control strategies; disease transmission; pandemics; real-time PCR; respiratory infections; severe acute respiratory syndrome coronavirus 2; whole genome sequencing; zoonoses.