Sesquiterpenes from Artemisia Sieversiana and their anti-inflammatory activities

Muaitaer Nuermaimaiti; Ablajan Turak; Qing Yang; Bixi Tang; Yi Zang; Jia Li; Haji Akber Aisa

doi:10.1016/j.fitote.2021.104996

Sesquiterpenes from Artemisia Sieversiana and their anti-inflammatory activities

Fitoterapia. 2021 Oct:154:104996. doi: 10.1016/j.fitote.2021.104996. Epub 2021 Jul 21.

Authors

Muaitaer Nuermaimaiti¹, Ablajan Turak², Qing Yang³, Bixi Tang⁴, Yi Zang⁵, Jia Li⁶, Haji Akber Aisa⁷

Affiliations

¹ The State Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi 830011, China; University of the Chinese Academy of Sciences, Beijing 100039, China.
² The State Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi 830011, China.
³ State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China; Department of Pharmacology, School of Pharmacy, Nanchang University, Nanchang 330006, China.
⁴ State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China; China Department of Pharmacology, School of Pharmacy, Fudan University, Shanghai 201203, China.
⁵ State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China; School of Pharmaceutical Science and Technology, Hangzhou Institute for Advanced Study, UCAS, Hangzhou 310024, China.
⁶ State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China; School of Pharmaceutical Science and Technology, Hangzhou Institute for Advanced Study, UCAS, Hangzhou 310024, China; Open Studio for Druggability Research of Marine Natural Products, Pilot National Laboratory for Marine Science and Technology (Qingdao), 1 Wenhai Road, Aoshanwei, Jimo, Qingdao 266237, China.
⁷ The State Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi 830011, China. Electronic address: [email protected].

PMID: 34302916
DOI: 10.1016/j.fitote.2021.104996

Abstract

Eight undescribed sesquiterpenes, including three dimeric guaianolides and five sesquiterpens, together with ten known ones, were isolated from the aerial parts of Artemisia sieversiana. Their structures were elucidated by extensive spectroscopic techniques and ECD calculation. The isolated compounds were tested for their anti-inflammatory effects against IL-1β, IL-6 and TNF-α in LPS-induced RAW 264.7 cells. Compounds 4, 9, 12, 15, 16 and 17 showed potent anti-inflammatory activities.

Keywords: Anti-inflammatory; Artemisia sieversiana; Dimeric guaianolides; Sesquiterpenes.

MeSH terms

Animals
Anti-Inflammatory Agents / isolation & purification
Anti-Inflammatory Agents / pharmacology*
Artemisia / chemistry*
China
Cytokines
Mice
Molecular Structure
Phytochemicals / isolation & purification
Phytochemicals / pharmacology
RAW 264.7 Cells
Sesquiterpenes / isolation & purification
Sesquiterpenes / pharmacology*

Substances

Anti-Inflammatory Agents
Cytokines
Phytochemicals
Sesquiterpenes