A surgical case of pediatric spinal medulloepithelioma

Kazuki Nakamura; Ken-Ichiro Matsuda; Takanobu Kabasawa; Toru Meguro; Akira Kurose; Yukihiko Sonoda

doi:10.1007/s00381-021-05293-7

A surgical case of pediatric spinal medulloepithelioma

Childs Nerv Syst. 2022 Feb;38(2):473-477. doi: 10.1007/s00381-021-05293-7. Epub 2021 Jul 26.

Authors

Kazuki Nakamura¹, Ken-Ichiro Matsuda¹, Takanobu Kabasawa², Toru Meguro³, Akira Kurose⁴, Yukihiko Sonoda⁵

Affiliations

¹ Department of Neurosurgery, Faculty of Medicine, Yamagata University, Yamagata-City, Japan.
² Department of Pathological Diagnostics, Faculty of Medicine, Yamagata University, Yamagata-City, Japan.
³ Department of Pediatrics, Faculty of Medicine, Yamagata University, Yamagata-City, Japan.
⁴ Department of Anatomic Pathology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan.
⁵ Department of Neurosurgery, Faculty of Medicine, Yamagata University, Yamagata-City, Japan. [email protected].

PMID: 34312708
DOI: 10.1007/s00381-021-05293-7

Abstract

Embryonal tumor with multilayered rosettes (ETMR), C19MC-altered was introduced to the World Health Organization classification of central nervous system tumors in 2016. It is characterized by amplification or fusion of the chromosome 19 microRNA cluster (C19MC) locus at 19q13.42. Medulloepithelioma also an ETMR but lacks C19MC alteration. We report a rare case of spinal medulloepithelioma in a 2-year-old boy and review the literature.

Keywords: C19MC; ETMR; Lumber.

Publication types

Case Reports

MeSH terms

Brain Neoplasms* / pathology
Central Nervous System Neoplasms*
Child, Preschool
Humans
Male
MicroRNAs* / genetics
Neoplasms, Germ Cell and Embryonal*
Neuroectodermal Tumors, Primitive* / diagnostic imaging
Neuroectodermal Tumors, Primitive* / surgery

Substances

MicroRNAs