TREM2 splicing emerges as crucial aspect to understand TREM2 biology

J Leukoc Biol. 2021 Nov;110(5):827-828. doi: 10.1002/JLB.2CE0521-264R. Epub 2021 Jul 27.

Authors

Miguel Moutinho^{1

2}, Gary E Landreth^{1

2}

Affiliations

¹ Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, Indiana, USA.
² Department of Anatomy, Cell Biology and Physiology, Indiana University School of Medicine, Indianapolis, Indiana, USA.

PMID: 34312904
DOI: 10.1002/JLB.2CE0521-264R

Abstract

Discussion on TREM2 splicing and its different transcripts with regard to the physiological function of TREM2 and its role in disease.

©2021 Society for Leukocyte Biology.

Publication types

Editorial

MeSH terms

Alternative Splicing
Animals
Humans
Membrane Glycoproteins / genetics*
Membrane Glycoproteins / metabolism*
Receptors, Immunologic / genetics*
Receptors, Immunologic / metabolism*

Substances

Membrane Glycoproteins
Receptors, Immunologic
TREM2 protein, human