Move it to lose it: Mitocytosis expels damaged mitochondria

Chahat Mehra; Lena Pernas

doi:10.1016/j.devcel.2021.07.001

Move it to lose it: Mitocytosis expels damaged mitochondria

Dev Cell. 2021 Jul 26;56(14):2014-2015. doi: 10.1016/j.devcel.2021.07.001.

Authors

Chahat Mehra¹, Lena Pernas²

Affiliations

¹ Max Planck Institute for Biology of Ageing, 50931 Cologne, Germany.
² Max Planck Institute for Biology of Ageing, 50931 Cologne, Germany; Cologne Excellence Cluster on Cellular Stress Responses in Ageing-Associated Diseases (CECAD), University of Cologne, 50931 Cologne, Germany. Electronic address: [email protected].

PMID: 34314697
DOI: 10.1016/j.devcel.2021.07.001

Abstract

Mechanisms by which cells remove damaged mitochondria extracellularly are unclear. Recent work by Jiao and colleagues in Cell shows that migrating cells expel dysfunctional mitochondria in membrane-bound structures called migrasomes to maintain mitochondrial homeostasis.

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MeSH terms

Homeostasis
Mitochondria*