Cohabitation With a Known Coronavirus Disease 2019 Case Is Associated With Greater Antibody Concentration and Symptom Severity in a Community-Based Sample of Seropositive Adults

Joshua M Schrock; Daniel T Ryan; Rana Saber; Nanette Benbow; Lauren A Vaught; Nina Reiser; Matthew P Velez; Ryan Hsieh; Michael Newcomb; Alexis R Demonbreun; Brian Mustanski; Elizabeth M McNally; Richard D'Aquila; Thomas W McDade

doi:10.1093/ofid/ofab244

Cohabitation With a Known Coronavirus Disease 2019 Case Is Associated With Greater Antibody Concentration and Symptom Severity in a Community-Based Sample of Seropositive Adults

Open Forum Infect Dis. 2021 Jul 24;8(7):ofab244. doi: 10.1093/ofid/ofab244. eCollection 2021 Jul.

Authors

Joshua M Schrock^{1

2

3}, Daniel T Ryan^{1

2}, Rana Saber^{1

2}, Nanette Benbow⁴, Lauren A Vaught^{5

6}, Nina Reiser^{5

6}, Matthew P Velez^{5

6}, Ryan Hsieh^{5

6}, Michael Newcomb^{1

2}, Alexis R Demonbreun^{5

7}, Brian Mustanski^{1

2}, Elizabeth M McNally^{5

6

8}, Richard D'Aquila⁹, Thomas W McDade^{3

10}

Affiliations

¹ Institute for Sexual and Gender Minority Health and Wellbeing, Northwestern University, Chicago, Illinois, USA.
² Department of Medical Social Sciences, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
³ Department of Anthropology, Northwestern University, Evanston, Illinois, USA.
⁴ Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
⁵ Center for Genetic Medicine, Northwestern University, Chicago, Illinois, USA.
⁶ Division of Cardiology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
⁷ Department of Pharmacology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
⁸ Department of Biochemistry and Molecular Genetics, Northwestern University, Chicago, Illinois, USA.
⁹ Division of Infectious Diseases, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
¹⁰ Institute for Policy Research, Northwestern University, Evanston, Illinois, USA.

Abstract

In a community-based sample of seropositive adults (n = 1101), we found that seropositive individuals who lived with a known coronavirus disease 2019 (COVID-19) case exhibited higher blood anti-severe acute respiratory syndrome coronavirus 2 spike receptor-binding domain immunoglobulin G concentrations and greater symptom severity compared to seropositive individuals who did not live with a known COVID-19 case.

Keywords: immunity; severe acute respiratory syndrome coronavirus 2; transmission.

Grants and funding

UL1 TR001422/TR/NCATS NIH HHS/United States