Linking peripheral CD8+ single-cell transcriptomic characteristics of mood disorders underlying with the pathological mechanism

Jing Lu; Lifeng Ma; Jiajun Jiang; Bochao Huang; Tingting Mou; Tingting Huang; Yi Xu; Ming Li; Lin Zhang; Xiaoping Han; Shaohua Hu

doi:10.1002/ctm2.489

Linking peripheral CD8⁺ single-cell transcriptomic characteristics of mood disorders underlying with the pathological mechanism

Clin Transl Med. 2021 Jul;11(7):e489. doi: 10.1002/ctm2.489.

Authors

Jing Lu^{1

2}, Lifeng Ma³, Jiajun Jiang^{1

2}, Bochao Huang¹, Tingting Mou^{1

2}, Tingting Huang^{1

2}, Yi Xu^{1

2}, Ming Li⁴, Lin Zhang⁵, Xiaoping Han^{3

6}, Shaohua Hu^{1

2

7}

Affiliations

¹ Department of Psychiatry, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.
² The Key Laboratory of Mental Disorder Management in Zhejiang Province, Hangzhou, China.
³ Center for Stem Cell and Regenerative Medicine, Zhejiang University School of Medicine, Hangzhou, China.
⁴ Key Laboratory of Animal Models and Human Disease Mechanisms of The Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Kunming, China.
⁵ Netherlands Institute for Neuroscience, An Institute of the Royal Netherlands Academy of Arts and Sciences, Amsterdam, The Netherlands.
⁶ Stem Cell Institute, Zhejiang University, Hangzhou, China.
⁷ Zhejiang University Brain Research Institute, Hangzhou, China.

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

CD8-Positive T-Lymphocytes / cytology
CD8-Positive T-Lymphocytes / metabolism*
Case-Control Studies
Depressive Disorder, Major / immunology
Depressive Disorder, Major / metabolism
Depressive Disorder, Major / pathology
Hepatitis A Virus Cellular Receptor 2 / genetics
Hepatitis A Virus Cellular Receptor 2 / metabolism
Humans
Mood Disorders / immunology
Mood Disorders / metabolism
Mood Disorders / pathology*
Sequence Analysis, RNA
Single-Cell Analysis
Transcriptome*
Up-Regulation

Substances

HAVCR2 protein, human
Hepatitis A Virus Cellular Receptor 2