Illuminating Plasmodium invasion by lattice-light-sheet microscopy

Markus Ganter; Friedrich Frischknecht

doi:10.1016/j.pt.2021.07.008

Illuminating Plasmodium invasion by lattice-light-sheet microscopy

Trends Parasitol. 2021 Sep;37(9):777-779. doi: 10.1016/j.pt.2021.07.008. Epub 2021 Jul 28.

Authors

Markus Ganter¹, Friedrich Frischknecht²

Affiliations

¹ Parasitology, Center for Infectious Diseases, Heidelberg University Medical School, Im Neuenheimer Feld 324, 69120 Heidelberg, Germany. Electronic address: [email protected].
² Parasitology, Center for Infectious Diseases, Heidelberg University Medical School, Im Neuenheimer Feld 324, 69120 Heidelberg, Germany; German Center for Infection Research, DZIF, partner site Heidelberg, Germany. Electronic address: [email protected].

PMID: 34332896
DOI: 10.1016/j.pt.2021.07.008

Abstract

Plasmodium merozoites invade erythrocytes in a stepwise manner through ligand binding, calcium signaling, and membrane deformation. Using a recently developed light-sheet microscope, Geoghegan et al. investigated invasion with unprecedented temporal resolution. Their spectacular footage revealed roles for host cell cholesterol and pore formation at the parasite-host cell interface.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Animals
Malaria*
Merozoites
Microscopy
Plasmodium*
Protozoan Proteins

Substances

Protozoan Proteins