Enyne Amides to Fused Pyridones: Scope and Limitations

J Org Chem. 2021 Oct 15;86(20):14177-14191. doi: 10.1021/acs.joc.1c00688. Epub 2021 Aug 2.

Abstract

Herein we present an investigation into the scope and mechanism for the synthesis of cyclopentyl and heterocyclic fused pyridones from the corresponding enyne amides. In the presence of a secondary amine, cyclization proceeds smoothly to form 5,6-bicyclic pyridones in 12-90% yield. The cyclization fails with enyne amides of six-membered and larger ring systems. The ring closure reaction is catalytic in nature with respect to the secondary amine and proceeds via sequential 1,6-addition of the amine, 6-exo-trig ring closure of the iminium intermediate, and subsequent elimination of the secondary amine. Computations show reduced conjugation between the enyne and amide for six-membered and larger systems, thereby providing an explanation for the inability of such enyne amides to form fused pyridones.

MeSH terms

  • Amides*
  • Catalysis
  • Cyclization
  • Molecular Structure
  • Pyridones*

Substances

  • Amides
  • Pyridones