A role for the cortex in sleep-wake regulation

Lukas B Krone; Tomoko Yamagata; Cristina Blanco-Duque; Mathilde C C Guillaumin; Martin C Kahn; Vincent van der Vinne; Laura E McKillop; Shu K E Tam; Stuart N Peirson; Colin J Akerman; Anna Hoerder-Suabedissen; Zoltán Molnár; Vladyslav V Vyazovskiy

doi:10.1038/s41593-021-00894-6

A role for the cortex in sleep-wake regulation

Nat Neurosci. 2021 Sep;24(9):1210-1215. doi: 10.1038/s41593-021-00894-6. Epub 2021 Aug 2.

Authors

Lukas B Krone^{1

2}, Tomoko Yamagata^{2

3}, Cristina Blanco-Duque^{1

2

4}, Mathilde C C Guillaumin^{2

3

5}, Martin C Kahn^{1

2

4}, Vincent van der Vinne^{1

2

6}, Laura E McKillop^{1

2}, Shu K E Tam^{2

3}, Stuart N Peirson^{2

3}, Colin J Akerman⁷, Anna Hoerder-Suabedissen¹, Zoltán Molnár⁸, Vladyslav V Vyazovskiy^{9

10}

Affiliations

¹ Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK.
² Sleep and Circadian Neuroscience Institute, University of Oxford, Oxford, UK.
³ Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.
⁴ The Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA.
⁵ Institute for Neuroscience, Department of Health Sciences and Technology, ETH, Zurich, Switzerland.
⁶ Department of Biology, Williams College, Williamstown, MA, USA.
⁷ Department of Pharmacology, University of Oxford, Oxford, UK.
⁸ Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK. [email protected].
⁹ Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK. [email protected].
¹⁰ Sleep and Circadian Neuroscience Institute, University of Oxford, Oxford, UK. [email protected].

Abstract

Cortical and subcortical circuitry are thought to play distinct roles in the generation of sleep oscillations and global state control, respectively. Here we silenced a subset of neocortical layer 5 pyramidal and archicortical dentate gyrus granule cells in male mice by ablating SNAP25. This markedly increased wakefulness and reduced rebound of electroencephalographic slow-wave activity after sleep deprivation, suggesting a role for the cortex in both vigilance state control and sleep homeostasis.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Dentate Gyrus / physiology*
Male
Mice
Mice, Transgenic
Neocortex / physiology*
Neurons / physiology*
Sleep / physiology*
Synaptosomal-Associated Protein 25 / deficiency
Wakefulness / physiology*

A role for the cortex in sleep-wake regulation

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