Post-ablation left atrial function impacts long-term recurrence of atrial fibrillation after ablation

Left atrial (LA) function can help predict various cardiovascular events. Catheter ablation for atrial fibrillation (AF) modifies baseline LA function through the maintenance of sinus rhythm and myocardial injury. We investigated the impact of post-ablation LA function on recurrence of AF after ablation and identified the predictors of reduced post-ablation LA function. A total of 616 patients who underwent AF ablation (paroxysmal, N = 310; non-paroxysmal, N = 306) were retrospectively examined with cardiac computed tomography at baseline and 3 months after the final ablation procedure. Post-ablation LA emptying fraction (LAEF_post) was calculated. We evaluated the association between LAEF_post and recurrence of AF after the final ablation procedure. Further, we assessed the predictors of reduced LAEF_post. The recurrence rate of AF was 72.7% after the final ablation procedure [median follow-up 48 months (48.0, 48.0), total number of ablation sessions: 1.4 ± 0.7]. Multivariate analysis revealed that LAEF_post was associated with the recurrence of AF (hazard ratio/10% increase: 0.62, 95% confidence interval: 0.51-0.75, P < 0.0001). LAEF_post had a mild predictive power for recurrence of AF (c-statistics: 0.670, optimal cutoff: 26.36%, P < 0.0001). The recurrence-free proportion among patients with reduced LAEF_post (< 26.36%, N = 100) and those with preserved LAEF_post (≥ 26.36%, N = 516) was 40% and 79%, respectively (P < 0.0001). The predictors of reduced LAEF_post were low pre-ablation LAEF, high pre-ablation LA volume, low body mass index (BMI), and female sex. Further, reduced LAEF_post was associated with the total number of ablation sessions and extra-pulmonary vein LA ablation. In conclusion, reduced LAEF_post was associated with recurrence of AF after ablation. Advanced LA remodeling, low BMI, and female sex could predict reduced LAEF_post. Although additional ablation was associated with reduced LAEF_post, it remains unclear whether reduced LAEF_post resulted from the additional ablation. Reduced LAEF_post might help stratify patients with ablation-refractory AF.