Ending on a sour note: Lipids orchestrate ferroptosis in cancer

Mike Lange; James A Olzmann

doi:10.1016/j.cmet.2021.07.011

Ending on a sour note: Lipids orchestrate ferroptosis in cancer

Cell Metab. 2021 Aug 3;33(8):1507-1509. doi: 10.1016/j.cmet.2021.07.011.

Authors

Mike Lange¹, James A Olzmann²

Affiliations

¹ Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA; Department of Nutritional Sciences and Toxicology, University of California, Berkeley, Berkeley, CA 94720, USA.
² Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA 94720, USA; Department of Nutritional Sciences and Toxicology, University of California, Berkeley, Berkeley, CA 94720, USA; Miller Institute for Basic Research in Science, University of California, Berkeley, Berkeley, CA 94720, USA; Chan Zuckerberg Biohub, San Francisco, CA 94158, USA. Electronic address: [email protected].

PMID: 34348094
DOI: 10.1016/j.cmet.2021.07.011

Abstract

Lipid metabolism is altered in the acidic tumor microenvironment. Here, the authors show that polyunsaturated fatty acid supplementation, together with concomitant inhibition of lipid droplet biogenesis, induces ferroptosis in acidic cancer cells. These findings highlight the potential to exploit cancer dependence on exogenous lipids as a therapeutic vulnerability.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Comment

MeSH terms

Ferroptosis*
Humans
Lipid Metabolism
Lipids
Neoplasms*
Tumor Microenvironment

Substances

Lipids

Grants and funding

R01 GM112948/GM/NIGMS NIH HHS/United States