Cytosponge-TFF3 Testing can Detect Precancerous Mucosal Changes of the Stomach

Clin Gastroenterol Hepatol. 2022 Jun;20(6):1411-1412. doi: 10.1016/j.cgh.2021.07.047. Epub 2021 Aug 3.

Abstract

Gastric intestinal metaplasia (GIM) and gastric atrophy (GA) are associated with increased risk of gastric cancer and are indications for endoscopic surveillance when affecting the proximal stomach.1 Endoscopic screening is not cost-effective in areas with low-moderate incidence of gastric cancer2; noninvasive methods to detect GIM/GA are currently lacking.3.

Publication types

  • Letter
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Endoscopy
  • Gastric Mucosa* / pathology
  • Humans
  • Metaplasia / diagnosis
  • Precancerous Conditions* / diagnosis
  • Precancerous Conditions* / epidemiology
  • Stomach Neoplasms* / diagnosis
  • Stomach Neoplasms* / epidemiology
  • Trefoil Factor-3

Substances

  • TFF3 protein, human
  • Trefoil Factor-3