Three dimensional bioelectronic interfaces to small-scale biological systems

Yoonseok Park; Ted S Chung; John A Rogers

doi:10.1016/j.copbio.2021.07.023

Three dimensional bioelectronic interfaces to small-scale biological systems

Curr Opin Biotechnol. 2021 Dec:72:1-7. doi: 10.1016/j.copbio.2021.07.023. Epub 2021 Aug 3.

Authors

Yoonseok Park¹, Ted S Chung², John A Rogers³

Affiliations

¹ Querrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL 60208, USA.
² Querrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL 60208, USA; Department of Biomedical Engineering, Northwestern University, Evanston, IL 60208, USA.
³ Querrey Simpson Institute for Bioelectronics, Northwestern University, Evanston, IL 60208, USA; Department of Biomedical Engineering, Northwestern University, Evanston, IL 60208, USA; Department of Materials Science and Engineering, Northwestern, University, Evanston, IL 60208, USA; Department of Electrical Engineering and Computer Science, Northwestern University, Evanston, IL 60208, USA; Department of Chemistry, Northwestern University, Evanston, IL 60208, USA; Department of Mechanical Engineering, Northwestern University, Evanston, IL 60208, USA; Department of Neurological Surgery, Northwestern University, Evanston, IL 60208, United States. Electronic address: [email protected].

PMID: 34358775
DOI: 10.1016/j.copbio.2021.07.023

Abstract

Recent advances in bio-interface technologies establish a rich range of electronic, optoelectronic, thermal, and chemical options for probing and modulating the behaviors of small-scale three dimensional (3D) biological constructs (e.g. organoids, spheroids, and assembloids). These approaches represent qualitative advances over traditional alternatives due to their ability to extend broadly into volumetric spaces and/or to wrap tightly curved surfaces of natural or artificial tissues. Thin deformable sheets, filamentary penetrating pins, open mesh structures and 3D interconnected networks represent some of the most effective design strategies in this emerging field of bioelectronics. This review focuses on recent developments, with an emphasis on multimodal interfaces in the form of tissue-embedding scaffolds and tissue-surrounding frameworks.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Electronics*
Organoids
Tissue Scaffolds*