Age-related cognitive impairment is associated with low serum concentrations of testosterone and CSF levels of amyloid beta 42 in male cynomolgus monkeys (Macaca fascicularis)

Huda Shalahudin Darusman; Tan Li Wern; Dondin Sajuthi; Steven J Schapiro; Jann Hau

doi:10.1111/jmp.12536

Age-related cognitive impairment is associated with low serum concentrations of testosterone and CSF levels of amyloid beta 42 in male cynomolgus monkeys (Macaca fascicularis)

J Med Primatol. 2021 Oct;50(5):270-272. doi: 10.1111/jmp.12536. Epub 2021 Aug 6.

Authors

Huda Shalahudin Darusman^{1

2}, Tan Li Wern¹, Dondin Sajuthi^{1

2}, Steven J Schapiro³, Jann Hau⁴

Affiliations

¹ Faculty of Veterinary Medicine, Bogor Agricultural University (IPB), Bogor, Indonesia.
² Primate Research Center, IPB, Bogor, Indonesia.
³ Department of Comparative Medicine, The University of Texas MD Anderson Cancer Center, Bastrop, TX, USA.
⁴ Department of Experimental Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

PMID: 34363401
DOI: 10.1111/jmp.12536

Abstract

Aged memory-impaired cynomolgus monkeys had significantly lower levels of cerebrospinal amyloid (Aβ₄₂ ) and serum testosterone compared with young animals and non-memory-impaired controls. Our findings confirm similar findings in the human and substantiate the usefulness of the cynomolgus monkey as a spontaneous model for aging-associated senile dementia of the Alzheimer type.

Keywords: aging; animal model; cognitive; non-human primates; sex hormone.

MeSH terms

Amyloid beta-Peptides*
Animals
Cognitive Dysfunction*
Macaca fascicularis
Male
Peptide Fragments
Testosterone

Substances

Amyloid beta-Peptides
Peptide Fragments
amyloid beta-protein (1-42)
Testosterone