External assessment of the EUROMACS right-sided heart failure risk score

Sci Rep. 2021 Aug 9;11(1):16064. doi: 10.1038/s41598-021-94792-3.

Abstract

The EUROMACS Right-Sided Heart Failure Risk Score was developed to predict right ventricular failure (RVF) after left ventricular assist device (LVAD) placement. The predictive ability of the EUROMACS score has not been tested in other cohorts. We performed a single center analysis of a continuous-flow (CF) LVAD cohort (n = 254) where we calculated EUROMACS risk scores and assessed for right ventricular heart failure after LVAD implantation. Thirty-nine percent of patients (100/254) had post-operative RVF, of which 9% (23/254) required prolonged inotropic support and 5% (12/254) required RVAD placement. For patients who developed RVF after LVAD implantation, there was a 45% increase in the hazards of death on LVAD support (HR 1.45, 95% CI 0.98-2.2, p = 0.066). Two variables in the EUROMACS score (Hemoglobin and Right Atrial Pressure to Pulmonary Capillary Wedge Pressure ratio) were not predictive of RVF in our cohort. Overall, the EUROMACS score had poor external discrimination in our cohort with area under the curve of 58% (95% CI 52-66%). Further work is necessary to enhance our ability to predict RVF after LVAD implantation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Cohort Studies
  • Female
  • Heart Failure / pathology*
  • Heart Ventricles / pathology*
  • Heart-Assist Devices
  • Humans
  • Male
  • Middle Aged
  • Prosthesis Implantation / methods
  • Pulmonary Wedge Pressure / physiology
  • Risk Assessment / methods
  • Risk Factors
  • Ventricular Dysfunction, Right / pathology*