A pharmacist-driven methicillin-resistant Staphylococcus aureus (MRSA) nasal polymerase chain reaction (PCR)-based testing protocol with a 70% acceptance rate for vancomycin discontinuation within 24 hours of negative results significantly reduced unnecessary vancomycin use with an estimated cost avoidance of $40 per vancomycin course. We found high concordance (141 of 147, 96%) of culture-based versus PCR-based MRSA nasal screening.
Keywords: MRSA; pneumonia; rapid diagnostics; stewardship; vancomycin.
© The Author(s) 2021. Published by Oxford University Press on behalf of Infectious Diseases Society of America.