Characteristics of High-Titer Convalescent Plasma and Antibody Dynamics After Administration in Patients With Severe Coronavirus Disease 2019

Open Forum Infect Dis. 2021 Jul 16;8(8):ofab385. doi: 10.1093/ofid/ofab385. eCollection 2021 Aug.

Abstract

We characterized the antibody composition of coronavirus disease 2019 (COVID-19) convalescent plasma (CCP) and the immunologic responses of hospitalized COVID-19 patients after receiving CCP or nonimmune fresh frozen plasma. Despite selection of CCP with significantly higher total immunoglobulin G than recipients, neutralizing antibody levels did not differ between donor plasma and CCP recipients.

Keywords: COVID-19; SARS-CoV-2; antibody avidity; convalescent plasma; neutralizing antibody.